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Concurrently, the expression levels of matrix metalloproteinase-12 (MMP-12) and neutrophil elastase were significantly elevated in the lung tissue of these mice—indicating that persistent bacterial colonization in the airways disrupts the “protease-antiprotease” balance in lung tissue, ultimately promoting COPD-like pathological changes
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2020 doi: 10.1016/j.carpath.2020.107233
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