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vitamin c lipid peroxidation slows primate aging by targeting iron-driven peroxidation: Cell Metabolism Radical scavenger
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After M1 polarization, macrophages release large amounts of Fe 2+ via ferritin autophagy mediated by nuclear receptor coactivator 4 (NCOA4), which not only promotes ferroptosis but also causes the further release of ferroptosis-promoting factors into the cornea, RPE, and RGCs, forming a vicious cycle in the ocular microenvironment
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10.1038/s41419-024-07114-6 99 PauloseB.ChhikaraS.CoomeyJ.JungH.VatamaniukO.DhankherO
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