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The prevalence of B12 deficiency after Roux-en-Y gastric bypass surgery is about 20%. Serum B12 levels <400 pg/mL are considered suboptimal because 5-10% of patients w neurologic symptoms related to B12 insufficiency

The main consequence of these oxidative insults is the impairment of rheological properties, as well as the alteration of O 2 transport capacity, factors that are particularly critical in pathological conditions such as diabetes, chronic inflammation, and aging

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6.2 Neurobiological and cognitive effects Neurobiological research suggests that AAS exposure may affect central nervous system functioning by inducing both structural and functional alterations