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Moreover, SREBP-2/APP/PS1 mice displayed synaptotoxicity, cognitive decline, tau hyperphosphorylation and neurofibrillary tangle formation in the absence of mutated tau, indicating that cholesterol, particularly mitochondrial cholesterol, can precipitate Aβ accumulation and tau pathology
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Mitochondrial Respiratory Chain—Complex IV (COX) Like SDHA, COX control content was also higher in the circular smooth muscle layer than in the longitudinal one (LM: 0.05 ± 0.03
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