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The 5xFAD transgenic mouse line has been genetically engineered to model features of AD through the expression of human amyloid precursor protein (APP) and presenilin-1 transgenes, which are associated with early-onset AD (Brody et al., 2017)
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10.1161/CIRCRESAHA.122.320184 [DOI] [PMC free article] [PubMed] [Google Scholar] 109
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