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Every participant assigned to retatrutide started at 2 mg once weekly and escalated step-wise every four weeks to their assigned target dose: 4 mg target: one step at 2 mg 9 mg target: steps at 2 mg, 4 mg and 6 mg 12 mg target: steps at 2 mg, 4 mg, 6 mg and 9 mg Note that the TRIUMPH-1 schedule contains no 8 mg step
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