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In a clinical study comparing erdosteine and NAC treatment in patients with chronic bronchitis, GSH levels in plasma and BAL were significantly higher after erdosteine treatment, compared to NAC [77]
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While DHAR1 has been localized to the peroxisomes, DHAR2 is cytosolic and DHAR3 encodes a dual-addressed chloroplast/mitochondrial enzyme (Figure 2)
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