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The occurrence of these equilibria between the different thiol-bound forms of mercury, including the neurotoxic methyl-mercury, and of cadmium has been demonstrated to occur as exemplified in Scheme 4 for mercury, through Nuclear Magnetic Resonance experiments both of biomimetic models [37,38,39] and of intact erythrocytes [39,40,41,42]

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2.1 Basic science research Investigation of diet impact on PD with research using animal models reveals that high-fat diets worsen nigrostriatal DA depletion in the brain and exacerbate neurotoxicity ( N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins used to induce animal models of PD