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Consistent with expectations, bona fide p53 targets including HDM2 and CDKN1A were among the most highly up-regulated genes in Control cells, whereas genes known to be negatively regulated by p53, such as E2F2 , were strongly down-regulated (el-Deiry et al, 1993
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However, considering the results of VFA measurements and phylum-level classification, the functional performance of the rumen microbiota improved in all groups
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