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Quantification of the maximum width of the mid-body of the corpus callosum, which stained positively with Luxol fast blue, demonstrated that untreated TBI mice had a statistically significant decrement of approximately 50% in myelinated axons compared to Sham control mice

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Activation of the Nrf2-ARE signaling pathway by I3C and DIM leads to increased expression of cytoprotective genes, reducing inflammation and oxidative damage [151]