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They noted a negative correlation between GPX3 expression levels and fibrosis levels across various treatment groups of the bromodomain inhibitor JQ1, suggesting a potential role of GPX3 in promoting the differentiation of cardiac fibroblasts into a protective state
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If results indicate inferior PK properties—such as high clearance, short half-life (t 1/2 ) and/or low bioavailability—PD effects will likely be sub-optimal
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