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In addition to individual intolerance, an increase in activity in the undesired direction, a sleep disorder, or an increase in libido may occasionally occur [1,4,5,6]

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In summary, our previous (11, 13) and present findings suggest that dual PPARα/γ-mediated inactivation of the “metabolic network,” which involves SIRT1 and PGC1α, may account for cardiac toxicity by compromising cardiac mitochondrial biology and energy homeostasis (Figure 9L)