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5-Amino-1MQ 5mg NNMT Inhibitor | Research Australia | GBL

Dimet-Wiley, Wu, and colleagues, also publishing in Scientific Reports in 2022, found that NNMT inhibition combined with calorie restriction altered gut microbiome composition in diet-induced obese mice — suggesting systemic metabolic effects that extend beyond adipose tissue, though the clinical significance in humans is unknown

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When evaluating adipose tissue in WT and β3-KO mice, researchers found that neither treatment significantly affected white adipose tissue mass in either genotype