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Mitochondrial dysfunction is thought to occur early in AD pathogenesis (Horowitz and Greenamyre, Neuroinflammation is a major characteristic of AD and represents a useful therapeutic target (Ong and Farooqui, Our discussion so far has focused on the cellular LIP, but 95% of functional iron in the body is in heme
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69,70 Notably, both mechanisms may interact, jointly driving disease progression in a complex, intertwined dance
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