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Glucose Toxicity in Beta-Cells
First, glutamyl-cysteine ligase (GCL) catalyzes the formation of gamma-glutamyl cysteine, which is linked to glycine to form GSH by GSH synthetase (GS)
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Cellular NAD+ NAD+ Preservation By blocking NNMT, 5-Amino-1MQ preserves the cellular NAD+ pool, an essential cofactor for more than 500 metabolic reactions and for the activation of sirtuins
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