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On the other hand, in the context of immunotherapy, collaborative efforts among diverse stakeholders for conducting combined drug treatments have yielded very few successful cases to date

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Complete healing of intestinal mucosa is the most desired goal in UC treatment (Supplementary Table S1, natural compounds can improve the barrier function of the UC mucosa through multiple perspectives, these include upregulation of the expression of tight junction protein, reduction in the intestinal mucosal, permeability, regulation of the intestinal mucus function, reduction of oxidative stress, and protection of the intestinal epithelial cells (Figure 4)