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In particular, the NRs farnesoid X receptor (FXR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor α and γ (PPARα and γ), liver receptor homolog 1 (LRH-1), and V-erbA-related protein 2 (EAR-2) have all been shown to regulate epithelial intestinal cell integrity and to modulate intestinal immune cell numbers and activities 21,22,23,24,25,26,27