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AOD-9604 is a synthetic peptide — a modified fragment of the C-terminal lipolytic domain of human growth hormone (the hGH 177-191 sequence with an added N-terminal tyrosine) referenced in lipid-metabolism research literature
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This effect was absent in Erα -/- mice but restored in Erα -/AA mice, indicating that nonclassical ERα signaling is sufficient for Akt activation in the vlVMN
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