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In contrast to our finding, another study has reported decreased testicular weight and density, reduced diameter and height of germ epithelium in seminiferous tubules, and decreased Leydig cell count in STZ-induced diabetic rats.46 This is a pertinent finding as Leydig cells function to synthesize and release testosterone that acts on peritubular cells and Sertoli cells within the testis to stimulate spermatogenesis.47,48 The disparities in results may be attributable to several factors

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Namely, as easily destroyed, standard growth peptidergic factors, while endogenously present, commonly request the addition of various carriers (i.e., peptide+carrier(s) complex) to show the needed effect when applied [10]