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For instance, the CHIP/HSP70 complex is essential for ubiquitinating misfolded Tau, and its deficiency in AD models leads to the accumulation of hyperphosphorylated Tau (Nadel et al., 2023)
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A systematic review of 15 experimental studies addressing non-spastic, non-trigeminal neuralgic pain noted that opioids were considered alongside antidepressants and anticonvulsants when evaluating efficacy and safety [165]
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