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Protein carbonyls are elevated in brains that have been exposed to free radical insults resulting from ionizing radiation that splits water into reactive OH radicals, metabolism of certain chemicals/pharmaceuticals, e.g., rotenone, that leads to inhibition of complex I of the mitochondrial electron transport chain, aging, and certain neurodegenerative disorders such as Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and AD (among other disorders) (33–37)

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caudatus , were described as chemotaxonomic markers ( Building on these initial applications, metabolomics was also applied to the study of stress response and nutritional quality