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A study in the Annals of Nutrition and Metabolism showed that combining carnitine, omega-3s, and polyphenols resulted in lower blood lipid levels and better cellular energy production, which has the implication of fat loss if the study had been of longer duration, it was only 12 weeks

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Furthermore, porphyrin can mitigate aggregation of critical autophagic machinery such as SQSTM1/p62 and microtubule associated proteins 1A/1B light chain 3B (LC3).[90] Interestingly, autophagy, which is also an important process in heme homeostasis and mobilization of iron, is mediated by HO-1 in the liver during injury and protects against hepatocyte death, suggesting a mechanism by which autophagy could be enhanced during porphyria.[6,91,92] Fluorescent porphyrins possess distinctive properties to cause organelle-selective protein aggregation through a mechanism called the “Porphyrination-deporphyrination cycle”.[90,93] PP-IX is central to this cycle