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Studies show that immune checkpoint blockade therapy activates CD8+ T cells to secrete IFN-γ, promoting ACSL4 growth, regulating cellular acyl-chain phospholipid-fatty acid binding to arachidonic acid (AA), and inducing tumor cell ferroptosis (110)
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Changes in membrane type-MMPs (MT-MMP), and a disintegrin and metalloproteinase with thrombospondin motif (ADAMTS) have also been observed in CVD and VLU
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