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As expected, cardiac-specific overexpression of wild-type NOX4 (WT-NOX4) decreased NADPH/NADP + and GSH/GSSG, which correlated with enhanced ROS production and cardiac dysfunction in mice under IR challenge (116)
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Anti-apoptotic protein upregulation Bcl-2 family regulation: Balance between pro-apoptotic (Bax, Bad, Bid) and anti-apoptotic (Bcl-2, Bcl-xL, Mcl-1) Bcl-2 family members determines cell survival versus death
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