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For example, the d-block metal ions Zn 2+ and Cu 2+ have been identified as endogenous modulators of neuronal transmission and synaptic plasticity and implicated in a number of pathophysiological conditions (Frederickson et al., 2000, 2005
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demonstrated the anti-inflammatory and antidepressant effects of SFN in a lipopolysaccharide model of depression, where a dietary intake of 0.1% glucoraphanin during juvenile and adolescent stages inhibited the development of depression-like phenotypes and alterations in synaptogenesis in adult brain regions (78)
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