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152 Dysregulation of Wnt/β-catenin signalling is often caused by mutations of various components in the pathway, particularly mutations or silencing of the Wnt tumour suppressor, which occurs frequently in various cancer types, such as adenomatous polyposis coli (APC) mutations, 193 Axin1/2 mutations, 194,195 GSK3β deletions, 196 inactivation mutations of E3 ubiquitin ligase RNF43, 196 and Znrf3

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393 GDF15 can also bind to the specific receptor GFRAL to activate the Ret proto-oncogene, which promotes ERK and Akt phosphorylation, resulting in decreased appetite