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Key Takeaways ✅ Standard cagrilintide dose : The maintenance dose is 2.4 mg administered subcutaneously once weekly , established through Phase 3 clinical trials ✅ Dose escalation matters : Gradual titration over 16-20 weeks minimizes gastrointestinal side effects and improves tolerability ✅ Combination therapy shows superior results : CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) demonstrated 22.7% mean weight loss at 68 weeks ✅ Dose-dependent effects observed : Phase 2 trials tested doses from 0.3 mg to 4.5 mg, with 2.4 mg offering optimal balance of efficacy and safety ✅ Proper administration technique : Injection sites include abdomen, thigh, or upper arm with rotation recommended to prevent lipodystrophy What Is Cagrilintide and How Does It Work

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2026 Jan 21;17(1):1902