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J Biol Chem (2010) 285:41525–32
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RESULTS The transsulfuration pathway contributes to de novo cysteine synthesis in cancer cells In order to investigate the cysteine acquisition strategies in cancer cells, we first examined the expression levels of CBS and CTH, two enzymes in the transsulfuration pathway, and the expression level of xCT, the regulatory component of the system Xc- amino acid antiporter (Figure 1A)
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