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Investigators frequently re-evaluate the biochemical parameters of BPC-157 and related central nervous system agents across independent trials to confirm activity via melanocortin receptor (MC3R/MC4R) or GnRH pulse-generator stimulation, monitoring crucial physiological markers and potential side effects such as temporary nausea, facial flushing, increased blood pressure, or mild transient headaches during systemic administration
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FIGURE 1 Given the role of GLP-1 in glycaemic control, the anti-apoptotic, growth-stimulating and insulin secretion-promoting effects on pancreatic β-cells, the ability to re-sensitize the cellular insulin-signaling, minor side effects, good tolerance by normoglycemic patients and the fact that GLP-1 does not desensitize, synthetic GLP-1R agonists have been on the market for decades to treat type 2 diabetes mellitus (T2DM) or, more recently, to improve weight loss (Drucker, 2018)
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