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168 Rho-associated coiled-coil-containing kinase (ROCK), also called Rho kinase, is a downstream effector of RhoA GTPase that appears to regulate several pathways involved in paracellular permeability, for example, extracellular signal-regulated kinase (ERK), NF-κB signaling, myocardin-related transcription factor-A (MRTFA), and MLCK pathways
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