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People with open wounds or active skin infections Those with a known copper allergy or sensitivity Anyone with persistent redness, itching, or irritation after use People with suspicious or changing pigmented lesions Pregnant or breastfeeding individuals, who should check with a clinician first According to the National Institutes of Health, published research on GHK-Cu remains dominated by small trials and lab studies, which is why long-term safety data is still limited (source: NIH PMC research review)

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Long-term functional maintenance of primary human hepatocytes in vitro