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There are in vitro observations that copper ions can inhibit the enzyme under specific laboratory conditions, but extrapolating this to a clinically meaningful, finasteride-like local DHT blockade on a human scalp is not supported by controlled human data

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40 Based on these studies, we examined the effect of DT-109 on GSH metabolism in monkey arteries and oxidative stress in vascular SMCs and have shown a concentration-dependent DT-109-mediated increase in arterial vascular GSH content as well as a decrease in oxidative stress in vascular SMCs