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In the tail conformation, the receptor intracellular core is presumably exposed, allowing for sustained interaction with G protein, which leads to the formation of the GPCR–G protein– β -Arr “super-complexes,” capable of stimulating G protein signaling while being internalized by β -Arrs (Thomsen et al., 2016)

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Mean ulcerative colitis activity index (UCAI) score was 157.4 ± 27.6 in UC patients