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Following weekly subcutaneous injection in clinical studies: Proportional exposure across the therapeutic dose range Steady-state achievement after multiple weekly doses Subcutaneous bioavailability enables once-weekly dosing Tissue distribution likely mediated by albumin binding and release Maximum plasma concentration (Cmax) ranges from 6.14 nmol/L to 170 nmol/L with doses of 0.16-4.5 mg, with higher doses used in monotherapy compared to combination regimens

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