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Eva Lovric, Department of Pathology, School of Medicine, University of Zagreb, Zagreb 10000, Croatia

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Moreover, we selected 5 mg/kg LicoA for the subsequent verification after the preliminary experiments, this dosage selection aligns with findings reported in a previous study ( Renal tubular epithelial cell (RTEC) injury and death are central to the pathogenesis and progression of CKD ( Ferroptosis, a form of iron-dependent cell death characterized by oxidative lipid damage and impaired antioxidant capacity, has emerged as a key player in cisplatin nephrotoxicity ( − , specifically its subunit xCT, impairs cystine uptake and GSH synthesis, weakening the antioxidant capacity of GPX4, the primary enzyme responsible for reducing lipid hydroperoxides