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To test this hypothesis, we used flow cytometry to measure how the expression of cathepsin B and the system xc- cystine/glutamate transporter SLC7A11 (xCT) scales with cell size (Fig
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Its prolonged stimulation of lipogenic genes indirectly encourages hepatic fat buildup and a subsequent pro-inflammatory state marked by the secretion of cytokines like TNF-α and IL-6, further exacerbating liver damage [89]
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