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The existence of the BBB that restricts the unique overall vascular permeability within the brain parenchyma reduces drug dissemination into the brain 2–5
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Among these, α‑syn oligomers (α‑synOs) are considered highly neurotoxic due to their ability to induce mitochondrial dysfunction, impair synaptic transmission, damage cellular membranes, and trigger intracellular inflammation and lysosomal stress [11]
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