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Increased expression of the antioxidant enzyme SOD enhances the ability to scavenge ROS, thereby prolonging the function of the corpus luteum and progesterone secretion [7,35]
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Resistant / Refractory Melasma For cases that do not respond to standard care, dermatologists may combine oral tranexamic acid, advanced topicals (such as newer agents like thiamidol or malassezin), RF microneedling, or carefully selected picosecond lasers
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