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In addition, circulating GLP-1 enters circumventricular areas of the CNS—such as the subfornical organ, the organum vasculosum of the lamina terminalis, the median eminence near the arcuate nucleus, and the area postrema—thanks to the partial permeability of the blood–brain barrier.2,3,6 In addition, NTS neurons, which receive peripheral afferent input, synthesise preproglucagon and serve as a source of GLP-1 within the CNS
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