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Acknowledgements The current work was supported by Chinese National Natural Science Funds (32125016, 32525002, U24A20371, and W2411011), a special program from the Ministry of Science and Technology of China (2021YFA1101000, 2022YFA1105200, 2022YFF0608400, and 2023YFA1800200, 2024YFC2707400), a Key R&D Program of Zhejiang Province (2023C03044 and 2024C03142), the Suzhou Innovation and Entrepreneurship Leading Talent Program (ZXL2022505, ZXL2022442), the Suzhou Medical College Basic Frontier Innovation Cross Project (YXY2303027, YXY2302017), the Joint Proiect of Pinnacle Disciplinary Group, the Second Affiliated Hospital of Chongqing Medical, Bo Xi Clinical Research Project of the First Affiliated Hospital of Soochow University (BXLC007), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Zhejiang Provincial Natural Science Foundation of China (LMS25H050002), and the National Traditional Chinese Medicine Comprehensive Reform Demonstration Zone Science and Technology Construction Project (GZY-KJS-ZJ-2025-092)

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The C718T polymorphism in the 3′-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension