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They define PCOS as the presence of two out of three criteria: hyperandrogenism (elevated levels of male hormones, assessed clinically -presence of acne, hirsutism- or biochemically), ovulatory dysfunction (oligo/anovulation, infrequent or absent ovulation), and/or polycystic ovarian morphology on ultrasound: either the presence of 20 or more follicles on a single ovary or ovarian volume above 10 cm3
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For gut motility, SCFAs activate GPR41/43 receptors on EC cells to stimulate 5-HT release and initiate peristaltic reflexes—a mechanism detailed in section 4.1.1 (Dalile et al., 2019)
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