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Moreover, in the intestinal and liver perfusion studies in Mrp2-deficient rats, the excretion of ethinylestradiol glucuronide into intestine and bile was significantly deceased, and the systemic exposure of ethinylestradiol glucuronide was 46-fold higher in Mrp-2 knockout mice due to its decreased excretion into lumen and bile (Zamek-Gliszczynski et al., 2011)
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