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A 2010 study by Tudor and colleagues in Regulatory Peptides reported that BPC-157 at 10 µg/kg or 10 ng/kg i.p., given 30 minutes before falling-weight traumatic brain injury in mice, directionally reduced unconsciousness and mortality across force impulses of 0.068–0.145 Ns, with the higher dose effective at the maximum 0.159 Ns impulse — though the abstract does not report numeric mortality percentages or p-values

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This mechanism of action may be related to the ability of BPC 157 to up-regulate the expression of genes such as Egr1 and Vegfr2, which play important roles in the growth and differentiation of neurons