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These findings collectively highlight the challenges of targeting the MET/HGF axis with ligand-blocking antibodies and underscore the need for refined biomarker-driven patient selection and a deeper understanding of MET pathway biology before advancing this class of agents in clinical practice

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These comprehensive studies establish a new paradigm for membrane-encased organelles or compartments in bacteria, but also raise many important questions that bear on P 1B -type ATPase function, assembly and mechanism like other work described below (Section 5.3.4), 936 The biological function of the DUF6110 protein FezA is completely unknown