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Nevertheless, due to the compensative mechanisms of the basal ganglia, thalamic nucleus, and the cerebellum, the clinical symptoms of motor deficits do not appear until 50%–70% of the dopaminergic neurons in substantial nigra are impaired and the dopamine levels in the striatum are depleted by approximately 80% (George et al., 2009

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[DOI] [Google Scholar] 6.Wu G., Fang Y.-Z., Yang S., Lupton J.R., Turner N.D