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The mechanism is now well understood: Cagrilintide binds AMY1R, AMY2R, AMY3R, and CTR in the brain โ the same receptors endogenous amylin uses โ activating Gs-coupled cAMP signaling in brainstem satiety centers to suppress appetite, delay gastric emptying, and reduce food intake
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Moreover, the neuropharmacological observations with antipsychotic drugs targeting GPCRs underpinned the formulation the major hypotheses of schizophrenia origin that implicated the dopaminergic, adrenergic, cholinergic, serotonergic, glutamatergic, GABAergic systems, and neuroinflammatory processes
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