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In 2010, the New York Times reported that: “Dermatologists nationwide are seeing women of Hispanic and African descent, among others, with severe side effects … from the misuse of skin-lightening creams, many with prescription-strength ingredients,” including steroids

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Administration of the GLS1-specific inhibitors BPTES and CB-839 reduced keratinocyte proliferation and chemokine production, decreased Th17 and γδ Th17-cell differentiation and epidermal proliferation, and improved the splenomegaly and skin lesions in a psoriasis-like mouse model (79)