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reported that very safe and inexpensive simple paravertebral intramuscular injections of ozone, minimally invasive, were quite effective in almost 80% of patients.⁶³ It has been proposed that medical ozone may modulate inflammatory processes by switching macrophages activity from M1 (inflammatory stage) to M2 (repair phase).⁶⁴ Regarding common osteoarthritis in the knee, a randomized controlled trial reported ozone to be equally effective as hyaluronic acid injections.⁶⁵ Valdenassi, et al

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