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The endophytic root-colonizing fungus Piriformospora indica can markedly promote plant growth and enhance the tolerance of host plants against abiotic and biotic stress

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Such modifications then activate NF-κB that is involved in the expression of proinflammatory mediators such as TNF and IL-6, 343,344 and that induces key steroidogenic molecules, like CYP11A1, CYP17A1 and StAR, leading to further aggravation of hyperandrogenemia