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mice lacking programmed cell death 1 develop lupus-like syndrome.28 – 31 To date, only limited lupus nephritis, rather than full systemic lupus syndrome, has been reported with the use of immune checkpoint inhibitors.32 As such, the effect of genetic variants of cytotoxic T-lymphocyte–associated protein 4, programmed cell death 1, and programmed death-ligand 1 on the risk or severity of immune-related adverse events is unknown

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